| Abstract: |
The effect of two antibilharzial drugs , namely , potassium anti-monyl tartrate and -niridazole on MAO activity in brain and liver of miceThe effect of brain nore pinephrine and dopamine contents as wellas the adrenal epinephrine content of the same animal .The present study was carried out in order to investigate the effect of two antibilharzial drugs, namely, potassium antimonyl tartrate and niridazole on MAO activity in brain and liver of mice, also the effect on brain nor~pinephrine and dopamine contents, as well as the adrenal epinephrine content of the same animals.Mice were infected with 100 cercariae per mouse.The adult worms were recovered from the hepatic po~tal system by perfusion with physiological saline, 7-8 weeks later.non-infeqted.The animals were distributed in groups1 )Norm~,,~~1JP receiving sa! ine and serve d\fH’~9rmalcontrol.2) Infeqted group receivirg saline’ and served 4fJ innfected control.3) Two norDll!U.groups, one given ~otassium antim?nyl tartrate’,’ i.p. for five consecutive days, and the.other given niridazole, orally for 10 consecutive days.4) Two infected gr0ups treated with the two drugs in the same manne r.Considering the effect of both drugs on brain and liver MAO activity, it was found that in normal animal~, potassium antimonyl tartrate and niridazole, produced ~Q significant change in brain and liver MAO activ ity, however the infected groups treated with tbese drugs showed a significant increase of liver activity as well as a significant decrease of brain MAC activity.Concerning the effect of the two drugs te8ted on the catecholamine contents in normal animals, it was found that they induced a significant increase of the’ adrenal epinephrine cont ant as well as a significant decrease of brain dopamine level. While niridazole significantly reduced the brain norepinephrine level, • potassium antimonyl tartrate failed to cause any change.:.
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