Effect of L-DOPA and Proprandolol on Certain Metabolic Aspects of Carbohydrate Metablism

Summary and ConclusionsL-DOPA is a drug which has been successfully used in the treatment of parkinsonism, Propanolol, on the other hand, is of a widespread use in the treatment of cardiac arrhythmia and hypertension. Since these drugs might be concurrently administered with other drugs such as sulphonylureas, we investigated the combined effect of L-DOPA or propanolol with tolbutamide or glibenclamide on certain aspects of carbohyd¬rate metabolism. The reason for choosing L-DOPA and propanolol is based on the findings that they induce marked changesin carbohydrate metabolism particularly blood glucose leveland plasma insulin activity.For the purpose of investigations, male albino rats weigh¬ing from 170-210 gm were divided into groups of six rats each.Tolbutamide sodium (100, 150 and 200 mg/kg) or glibenclamide sodium, (0.5, 0.75 and 1mg/kg) was injected I.P. in rats in six groups. Two additional groups were served as controls for tolbutamide sodium and glibenclamide sodium respectively. Other groups were used for L-DOPA (200 mg/kg I.P.), L-DOPA (200 mg/Kg I.P.) + tolbutamide (150 mg/kg I.P.) and L-DOPA (200 mg/kg I.P.) + glibenclaraide (0.75 mg/kg I,P..)