Analytical Study of some Pharmaceutical Hydrazine Derivatives

The present work is basically concerned with a studyof the chemical analysis of these artificial sweeteners with an em~hasis on methods of detection and assay. It falls into four main parts. The first part is devoted to saccharin sodium. It is divided into four sections. The first one is a literary review of the methods of analysis and detection o~ saccharin sodium. The second deals with the performance and comparison of some of the pharmacopoeial procedures. The third is for the determination of saccharin sodium by Parikhts procedure and two modifications. The fourth nndertakes the determiination of saccharin sodium through its cobalt salt complexoometrically and .polarographically. The second part is concerned with sodium cyclamate. It is divided into three sections. The first section deals with the methods of analysis and detection in aVailable literature, In the second one, some official methods have been tried. The third provides a description of a spectroophotometric titration procedure. The third part is devoted to sorbitol. It is divided into two sections. The first section provides a literary review of the methods of analysis and detection of sorbitol. In the second, a complexometric procedure for the determinaation of sorbitol through its copper salt is described. The fourth part is concerned with mixtures of some arGif~cial sweeteners and falls into two seotions. ~he first section presents a literary review of the methods of analysis and detection. The second undertakes to apply the knowledge and experience gained in the foregoing parts to the analysis of mixtures of some artificial sweeteners. The widespread use of hydrazine den va ti ves in the treatment of different diseases mWces it desirable to search for a convenient method for its mioroanalysis in its pharmaoeutioal forms especially by using electroochemical teohniques. Polarography has been ohosen for the purpose. Accordingly the aim of this work is to study the polarographic; behaviour of the hydrazine deriivatives under investigation so that one would be able to choose the best oonditions for its precise and accurate deternrination both in the pure w1d pharraaoeutical forms. The thesis falls ir! eight parts.