A technological study on direct compression of tablets

Most therapeutic agents lack the compression and flow characteristics required for tablet in on a tablet press and must be processed prior to the tableting opera¬tions. Classically, the techniques of granulation either the wet method or ,the dry granulation method, have been used for this purpose. Each of these time-consuming procedures often necessitates the use of specialized equipment. Wet granulation is unsuitable for materials that are heat or solvent labile. In addition, the incorporation of active ingredients into granules often loads to decreased drug availability.At present, one of the most promising ; alternatives to granulation techniques is direct compression,, It is for this reason*that the concept of compressing pharmaceuticals directly into tablets has received much attention in the past decade.