Synthesis of certain anilides likely to possess anaesthetic activity

Synthesis of certain Anlides likely to possess Anaesthetic Activity.Absreact of thesis aubmitted by refaat Husein Omar , for the Master Degree in pharmaceutical Sciences ( Organic Chemistry )A general yrarey of local anaesthetic drugs is presented. The synthesis of nev; W-substituted anilides structurally related to some active local anaesthetics is described, A critical discussion, of the experimental results attainei wi fch an adequate interpretation is advanced. Local anaesthetic activity testing of some of the new compounds is included.ollowing unavailable intermediate :The present investigation involved the synthesis of the1- Mesitylene.2- Nitroiaesitylene.3- Mesidine.4- U -Chloro-K-acetylmesidine,