Gastric cancer is the fourth most common cancer and the second leading cause ofcancer-related death worldwide. In 200P, about 880 000 people were diagnosed with gastriccancer and approximately 650 000 died of the disease.Because of the low cure rate and theadvanced stage at which many patients present, palliative strategies are an essentialcomponent of gastric cancer management.Surgical palliation of advanced gastric cancer mayinclude resection or bypass, alone or in combination with endoscopic or percutaneousinterventions. Such interventions have been proposed not only to improve symptom control,but also to eliminate potential complications (bleeding, obstruction, pain, perforation,debilitating ascites) caused by the primary tumor.Palliative or noncurative resection is definedby the presence of any gross or microscopic residual tumors remaining postoperativelyregardless of whether the surgical attempt was originally palliative or curative.The proponentsfor palliative gastrectomy assume that by removing the major tumor bulk by partial or totalgastrectomy, one can avoid complications arising from the tumor such as tumor bleeding,obstruction and perforation. Moreover, by reducing the risk of occurrence of tumorcomplication, one can reduce the number of recurrent hospital admissions and, hence, thepatient can enjoy a better quality of life (QOL) and a longer hospital-free survival (HFS)period. The other possible advantage of performing palliative resection is cytoreduction. Byremoving the tumor bulk, theoretically, palliative chemotherapy or radiotherapy can be moreeffective and less tumor-related complications will occur during therapy.Conversely,opponents would argue that surgical intervention is associated with significant risks. Mostpatients with advanced malignancy have poor physical and nutritional status, and treatingtheir symptoms with a major surgical resection may result in a higher rate of morbidity andmortality. This is especially true in the case of resection of a proximal gastric carcinoma,In our study, mite was statistical significant from other allergens as hay, wool, tobacco and cotton among allergic asthmatic patient {Mite (66,7%) then Hay(12.1%),Wool(9%), Tobacco(6.1%) and Cotton (6.1%)} (P=0.000 significant).In our study, the mean of IgE in asthmatic allergic patients was the highest followed by non allergic then the control groups and the differences was statistically significant.In our study,the mean value of IgE was highly statistical significant increase in severe asthma compared to moderate & mild types of asthma & the mean value of IgE was highly statistical significant increase in moderate asthma compared to mild asthma (P=0.000 significant).In our study, the mean of T.N.F-α in asthmatic allergic patients were the highest followed by non allergic then the control groups and the differences was statistically significant.In our study, the mean value of T.N.F-α was highly statistical significant increase in severe asthma compared to moderate & mild types of asthma & the mean value of T.N.F-α was highly statistical significant increase in moderate asthma compared to mild asthma.In our study, non- statistical significantly between severity of asthma and allergy.In our study, ROC curve analysis ,which differentiate between T.N.F-α and IgE of the allergic asthmatic group, shows that the best cut off point for T.N.F-α was 42 pg/ml while for IgE was 247.5U/ml. T.N.F-α had a sensitivity of 97%, specifity of 96.3%, positive predictive value of 97% and negative predictive value of 96.3%. IgE had a sensitivity of 93.9%, specifity of 92.6%, positive predictive value of 93.6% and negative predictive value of 92.6% In conclusion, this work aims to evaluate the diagnostic and prognostic role of T.N.F-α & total IgE in diagnosis and management of asthma. Our data show that T.N.F-α & total IgE affect the severity of asthma and its prognosis.