| Abstract: |
Metabolic syndrome is defined according to International Diabetes Federation ( IDF 2006) as central obesity defined as waist circumference≥.94cm for male and≥.80cm for female for arabe population ,and two of the following;Triglyceride≥150mg\dl., HDL-C≥40mg.\ dl for rmen, 50mg≥dl for women,BP.≥ 130\85mmHg andFPG≥100mg\.dl.Most metabolic syndrome patients are at a much greater risk for atherothrombotic events than are patients who have impaired glucose tolerance or type 2 DM (Lillioja et al, 1992 & Martin et al,1992) .The components of metabolic syndrome and their cumulative effect on cardiovascular disease (CVD) result in significant morbidity and mortality(Lakka et al,2002).In the metabolic syndrome, in addition to glucose toxicity, chronically elevated levels of free fatty acids result from increased lipolysis of the abdominal visceral adipose depots, and lipotoxicity develops. Elevated levels of free fatty acids produce the lipotoxicity that led to glucose-induced insulin secretion and worsens the IR at the liver and muscle cells(Boden, 1996) .In the last 2 decades, research has revealed much about the pathophysiology of metabolic syndrome at the cellular, tissue, and organ levels. Abdominal obesity is the most prevalent component and is likely to increase in importance as the epidemic of obesity continues to grow. Obesity is an alarming public health problem in the Arab population and is mainly responsible for the rising prevalence of metabolic syndrome, In addition, obesity contributes to ill health by increasing the prevalence of type 2 DM and coronary heart disease. Hypertension is also an important component of metabolic syndrome, particularly in older individuals, and is often poorly controlled in the general population (Tkac ,2005)..
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