Endometrial Cytopathology In Patients With Chronic Liver Disease And Hepatic Dysfunction

Abstract In conclusion the metabolism of estrogen is intimately dependent upon the integrity of the liver. Diseases like infectious hepatitis or parasitic infestation is often accompanied by gynecomastia and other evidence of hyperestrogenism. The liver has a definitive threshold capacity of oxidizing estrogen, when this oxidative function is impaired the blood level estrogen increases, this hyper estrogenic state which is persistent and unopposed will ultimately results in hyperplasia of endometrium with or without atypia and even carcinoma , so this group of patients should be screened for early detection of such changes.