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Interleukin 13 Receptors as Biochemical Markers in Atopic Patients
Faculty
Medicine
Year:
2011
Type of Publication:
Article
Pages:
101-107
Authors:
Shalaby, S. M, Sabbah, N. A, Hussein, Y. M, Ahmad, A. S, Ibrahem, M. M, Elsherbeny, H. M, El-Shal, A. S
Journal:
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY ESMON PUBLICIDAD S A
Volume:
21
Research Area:
Allergy; Immunology
ISSN
ISI:000295388400003
Keywords :
Atopic patients, Interleukin 13, Asthma
Abstract:
Background: Interleukin (IL) 13, a type 2 helper T cell (T(H)2), is an important regulator of inflammatory immune responses. It mediates its action through a receptor complex consisting of IL-13R alpha 1 and IL-4R alpha, IL-13R alpha 2 binds IL-13 with high affinity and is thought to act primarily as a decoy receptor, sequestering IL-13 and thus inhibiting its action. Our aim was to clarify the role of these receptors in the diagnosis and follow-up of atopic patients. Methods: We genotyped the 1398A>G polymorphism in the IL-13R alpha 1 gene using restriction fragment length polymorphism for causal genetic diversity and measured serum levels of IL-13R alpha 2 in 105 atopic patients suffering from atopic asthma, atopic dermatitis, and atopic rhinitis (35 each). We compared the results with those of 35 nonatopic control individuals. Total immunoglobulin (Ig) E and serum IL-13R alpha 2 were measured using enzyme-linked immunosorbent assay, and the eosinophil counts were recorded. Results: A significant increase in serum IL-13R alpha 2 levels was recorded in the 3 atopic groups compared with the control group (P<.001), as well as a significant increase in total IgE levels and eosinophil counts. No significant association was found between 1398A>G and atopy other than a suggestive association between this polymorphism and raised total serum IgE levels in all 3 atopic groups (P<.001). Conclusions: These findings indicate that IL-13R alpha 2 plays an important role in atopy and that increased levels in different groups highlight its regulatory role in the development of atopic symptoms. The 1398A>G polymorphism might be involved in the production of IgE.
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