Assessment of Coronary Blood Flow in Children on Hemodialysis

we aimed at assessing the coronary flow reserve in children on regular hemodialysis which reflects the functional capacity of microcirculation to adapt to blood demand during increased cardiac workMethods. forty end-stage renal failure patients 0n regular hemodialysis were enrolled in this study (24 males, 16 females). twenty healthy subjects (12 males, 8 females) were included in the control group. Biochemical parameters and high-sensitivity C-reactive protein (hs-CRP)] of patients were recorded before dialysis. we performed transthoracic Doppler recording of diastolic coronary flow velocity in the LAD at baseline and after maximal vasodilatation by dipyridamole infusion . CFR was defined as the ratio of hyperaemic to basal averaged peak flow velocity.Results. CFR was smaller in haemodialysis (HD) patients than in controlsubjects (1.63 ± 0.14 versus 2.630.34, P = 0.001) due to the higher baseline peak coronary velocities in the former(52.35.1versus24.43.6,p=0.001)and thelower peak coronary velocities during hyperaemia. (52.35.12versus 626.15, p=0.002)Conclusions. CFR is signifiantly reduced in children with CRF on regular hemodialysis.keywords: anaemia• coronary flow reserve• echocardiography• haemodialysis• left ventricularhypertrophy.•