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Interleukin-13 Receptor A1 Gene Polymorphism and IL-13 Serum Level in Atopic and Non-atopic Egyptian Children
Faculty
Medicine
Year:
2011
Type of Publication:
Article
Pages:
523-534
Authors:
Shalaby, Sally M, Hussein, Yousri M, Hassan, Tamer H, Mohamed, Randa H, El-Tarhouny, Shereen A, El-Sherbeny, Hend M, Mohamed, Noha A
DOI:
10.3109/08820139.2011.565106
Journal:
IMMUNOLOGICAL INVESTIGATIONS INFORMA HEALTHCARE
Volume:
40
Research Area:
Immunology
ISSN
ISI:000291309300005
Keywords :
Atopy, Interleukin 13 receptor alpha 1, Single nucleotide polymorphism
Abstract:
Objectives: To assess serum interleukin (IL) 13 levels in atopic diseases and to determine the role of IL-13R A(1) gene polymorphism (+ 1398 A/G) in pathogenesis of these diseases. Methods: Serum total immunoglobulin (Ig) E and IL-13 levels were measured by ELISA and the IL-13R A(1) gene (+ 1398 A/G) was screened by PCR-restriction fragment length polymorphism (RFLP) in 240 asthmatic children (120 atopic and 120 nonatopic) and 120 allergic rhinitis patients compared with 120 age-matched controls. Results: No significant association was observed between genotype frequencies of the IL-13R A(1) + 1398 A/G polymorphism in patients groups compared to in controls. There was a significant increase in serum levels of total IgE \& IL-13 towards heterozygous AG and homozygous GG than homozygous AA in atopic asthma, non-atopic asthma and allergic rhinitis groups (P < 0.001 for each). A highly significant increase of serum IL-13 in atopic asthma as compared with controls (P < 0.001) and with nonatopic asthmatics (P < 0.001) was shown. Conclusion: The IL-13R A(1) + 1398 A/G polymorphism does not contribute to asthma or allergic rhinitis susceptibility, yet serum IL-13 can be used as a marker in atopic diseases and to differentiate between atopic and non-atopic asthma.
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