Preload Dependence Of Doppler Tissue Imaging

Conventional echocardiographic (ECHO) parameters of left ventricular (LV) and right ventricular (RV) systolic and diastolic function have been shown to be load-dependent; however, the impact of preload reduction on tissue Doppler (TD) parameters of LV and RV function is incompletely understood (Drighil et al.,2008).In our study we aimed to evaluate the effect of increased preload on left and right ventricular systolic and diastolic functions in patients with chronic renal failure, & determine the effect of preload reduction by hemodialysis on conventional echo and Doppler tissue imaging derived indices of systolic and diastolic function of left and right ventricle.So we enrolled 40 patients with end stage renal disease and on regular hemodialysis (15 male, 25 female, ages 8–18 years, mean age 12.3± 2.3 years).Conventional echo and Doppler tissue imaging were performed to compare indices with 20 healthy control children indices also compare pre with post dialysis indices.The results revealed that systolic functions: EF% (ejection fraction) & FS% (fractional shortening) had no significant decrease in patients compared with control group and there was no significant decrease in post dialysis compared with pre dialysis indices.The results of Tricuspid inflow revealed that there was significant decrease in early diastolic functions (E) in patients compared with control, but late diastolic velocity (A) had no significant decrease in patients. In comparison between pre and post dialysis there was sign. decrease in diastolic (E) velocity in post dialysis compared with pre dialysis