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Association of tumor necrosis factor alpha and its receptor polymorphisms with rheumatoid arthritis in female patients
Faculty
Medicine
Year:
2011
Type of Publication:
Article
Pages:
192-196
Authors:
Hussein, Yousri M, Alzahrani, Saad S, El-Shahawy, Eman E, Mohamed, Randa H, Pasha, Heba F
DOI:
10.1016/j.cellimm.2011.06.023
Journal:
CELLULAR IMMUNOLOGY ACADEMIC PRESS INC ELSEVIER SCIENCE
Volume:
271
Research Area:
Cell Biology; Immunology
ISSN
ISI:000297658400028
Keywords :
TNF, Polymorphisms, Rheumatoid arthritis
Abstract:
Rheumatoid arthritis (RA) is a chronic autoimmune disorder associated with altered expression of pro-inflammatory cytokines. We aim to elucidate the association between the -308G/A polymorphism of the TNF-alpha gene and 196M/R polymorphism in TNFRII gene and susceptibility and severity of RA. One hundred and seventy-two RA patients and one hundred and sixty controls were enrolled in the study. Polymorphisms (SNPs) at position -308 of TNF and -196 of TNFRII genes were determined using restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP). TNF AA genotype was more prevalent among the patients. GG genotype was significantly more likely to have erosive arthropathy. TNFRII RR genotype was more prevalent among the patients. Our findings suggest that the 308AA genotype of TNF-alpha and TNFRII 196M/R polymorphism are associated with RA susceptibility. While only the 308GG genotype of TNF-alpha is associated with RA severity. (C) 2011 Elsevier Inc. All rights reserved.
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