The first human liver transplant was carried out by Thomas Starzl in Denver, Colorado, USA in 1963 in a child with biliary atresia.Many other advances have been made in the past three decades. Improvements in preoperative assessment and medical management of potential transplant candidates as well as better peri-operative and post-transplant care have undoubtedly enhanced outcomes. Progress in the treatment of infective complications and the development of more selective immunosuppressive agents have seen survival approaching 90% at one year.With increasing experience and due to technical developments, living-related liver donation of liver segments II and III has matured as a standard procedure in pediatric liver transplantation. A transplant survival rate of 94% during the first year after grafting can be achieved with this method.