Pyrethroid Toxic Effects on some Hormonal Profile and Biochemical Markers among Workers in Pyrethroid Insecticides Company

Background: As Pyrethroids use is common and likely increasing worldwide, so more researches are needed to know its hazardous effects. Objectives: This study was designed to evaluate chronic toxic effects of synthetic pyrethroids on some hormonal profile (testosterone, estrogen, progesterone \& thyroid hormones), respiratory system, liver and kidney functions, in addition, trying to clarify some underlying mechanisms of toxicity through measuring total antioxidant capacity, lipid peroxidation markers (malondialdhyde), and IgE among workers exposed to pyrethroids. Subjects and Methods: The study included eighteen workers of both sexes exposed to pyrethroids in pyrethroid Insecticides Company. Twenty non exposed workers from the administrative workers of Faculty of Medicine Zagazig University were selected as a control group. All participating workers were interviewed using a precomposed questionnaire, furthermore they were examined clinically and investigated by measuring some blood parameters as testosterone, estrogen, progesterone, thyroid hormones (T-3, T-4 and TSH), IgE, ALT, AST, creatinine, urea, total-antioxidants and malondialdehyde according to standard procedures. Results: The studied groups were matched as regard gender, age, duration of work, marital status, income, residence and smoking habit. There was a highly significant prevalence of headache, cough \& wheeze among exposed workers compared to control group (p < 0.001). Moreover, the exposed group had significantly lower values of testosterone, T-3, T-4, and pan-antioxidants, as compared to control group (p < 0.001). Also, there was a higher significant values of TSH, IgE, ALT, AST and malondialdehyde among exposed workers as compared to control group (p < 0.001). Conclusion \& Recommendations: Chronic exposure to pyrethroid insecticides may cause endocrine disrupting effects, respiratory problems, liver function impairment, beside oxidative stress and lipid peroxidation. So we recommended, improving working condition. Restriction of unlimited use of pyrethroid insecticides especially at home and agricultural purposes. Further researches are needed to evaluate pyrethroids effect on large sample to obtain detailed information about the exposure route, pathways, other mechanisms of toxicity and other health hazards. {[}Sahar A. Abou El-Magd; Laila M. E. Sabik and Amira Shoukry. Pyrethroid Toxic Effects on some Hormonal Profile and Biochemical Markers among Workers in Pyrethroid Insecticides Company. Life Science Journal. 2011; 8(1): 311-322] (ISSN: 1097-8135). http://www.lifesciencesite.com.