Histological Study On The Effect Of Rosuvastatin On The Renal Cortex Of Adult Male Albino Rats And The Possible Protective Role Of Co Enzyme Q 10

Introduction: Statins (including rosuvastatin) represent the drugs of choice for treatment of hypercholesterolaemia and reducing the risk of cardiovascular diseases. They posses multiple other lipid-independent effects as improvement of endothelial function, inhibition of vascular inflammation and amelioration of oxidative stress. Both physicians and patients have demonstrated valid concerns about the safety associated with the use of such medications.Aim of the Work: This study aimed to evaluate the histological and immunohistochemical changes in the adult male albino rats׳ renal cortex treated with rosuvastatin and the possible protective role of co-enzyme Q10.Materials and Methods: Sixty adult male albino rats were classified into control group (Ia, I b and Ic), treated group (IIa and IIb) and groupIII (follow up group). Renal cortex was stained with H&E, Masson’s trichrome, PAS, immunohistochemically for iNOs enzyme and electron microscopic examination.Results: Rosuvastatin administration in group (IIa), led to acute tubular necrosis and acute interstitial nephritis, in addition to distortion of the renal barrier which slightly decreased with coQ10 adminstration and completely disappeared with stoppage of the treatment.Conclusion: These findings implied that rosuvastatin induced nephrotoxic effect associated with oxidative stress with self recovery after stoppage of drug adminstration. So, rosuvastatin should be used cautionary.Key Words: Statins; rosuvastatin; renal cortex; tubular toxicity; oxidative stress; co-enzyme Q10 and recovery.