Assessmenmt of Some Cardiovascular and Biochemical Parameters Induced in Rats by Chronic Noise Stress

The present study aimed to assess some cardiovascular and biochemical parameters induced in rats by chronic noise stress. Moreover, changes produced in the histological architecture of the heart and aorta were also investigated. For this purpose, forty healthy adult male albino rats weighting 200 +/- 30 grams were used in the study. They were divided equally into two main groups; noise group (n=20) which was exposed to chronic white noise stress (100 dBA) 6 hours daily for 30 days and control group (n=20) which was kept away from any stress source and was hold in the same conditions. After 30 days, animals exposed to chronic noise stress exhibited significant increase in the heart rate, systolic, diastolic, and mean arterial blood pressure associated with a significant decrease in serum Mg++ levels. There was a strong significant negative correlation between reduction in serum Mg++ and elevation in mean arterial blood pressure. A significant elevation in serum levels of ACTH, corticosterone, and leptin was detected after exposure to noise stress. Moreover, the data obtained indicated that, under these conditions of chronic and high noise exposure levels, there was significant increases in the serum levels of TC, TGs, VLDL and LDL-C and a significant decrease in the level of serum HDL-C. The histopathological examination of the heart tissue demonstrated that, exposure of rats to chronic noise stress has resulted in areas of hemorrhage inbetween the cardiac myocytes, necrosis and small areas of myocardial infarction. Microscopic examination of the aorta showed the presence of thickening of elastic fibers in the media with perivascular infiltration by acute inflammatory cells (neutrophils \& eosinophils) and non-specific inflammatory cells. {[}Samia M. Sanad, Ali K. Asala, Nabil A. Soliman and Rabab A. Balata. Assessmenmt of Some Cardiovascular and Biochemical Parameters Induced in Rats by Chronic Noise Stress. Life Science Journal 2011; 8(4): 1120-1141]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 138