Intellectual evaluation of beta thalassemia major patients in Zagazig University Hospitals

The thalassemias are inherited disorders of hemoglobin synthesis. Their clinical severity widely varies, ranging from asymptomatic forms to severe or even fatal entities. Regular blood transfusions are mandatory for long term survival, but over a period of years these cause a secondary state of tissue iron overload.Iron overload causes most of the mortality and morbidity associated with thalassemia. Excess iron is deposited in major organs, resulting in organ damage. The organs that are at risk of damage due to iron overload include the liver, heart, pancreas, thyroid, pituitary gland and other endocrine organs.