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Histopathological and Immunohistochemical Studies on the Adrenal Cortical Tumors of Egyptian Patients
Faculty
Science
Year:
2011
Type of Publication:
Article
Pages:
970-978
Authors:
Samia, M. Sanad, Mahmoud, A. El-Baz, Omar, I. Ghonemy, Hassan, F. Abo El-Nazar
Journal:
LIFE SCIENCE JOURNAL-ACTA ZHENGZHOU UNIVERSITY OVERSEAS EDITION MARSLAND PRESS
Volume:
8
Research Area:
Life Sciences \& Biomedicine - Other Topics
ISSN
ISI:000303526000124
Keywords :
Histopathology, Immunohistochemistry, Adrenal cortical tumors, Cytokeratin, Vimentin
Abstract:
The presnet study provides guidelines for the diagnosis of adrenal cortical tumors in Egyptian patients. This retrospective study included 40 patients of adrenal cortical tumors (28 adenoma and 12 carcinoma). They were admitted to Mansoura Urology and Nephrology Center between 1985-2002. All patients were surgically treated by adrenalectomy. Patients with adenoma were followed for a period ranging from 24-67 months. Clinical and laboratory improvement of adenoma was observed. Nine patients of carcinoma died of distant metastasis after 8 months and the other 3 patients were still alive 24 months after surgery. Hyaline globules which are PAS positive were detected in adrenal cortical adenoma and carcinoma and both types were positive for reticulin stain. Immunohistochemically; cytokeratin was expressed in 22/28 cases of adenoma and all cases 12/12 of carcinoma. Vimentin was expressed in 20/23 cases of adenoma and 8/12 cases of carcinoma. The present study concluded that: (1)- Reticulin staining is useful for the diagnostic differentiation of adrenal cortical carcinoma from adrenal cortical adenoma. (2)- The expression of cytokeratin and vimentin is helpful in diagnosis, but the histopathological examination of paraffin sections remains the basic method. (3)- No significant correlation between immunohistochemical pattern of adrenocortical tumors and survival was observed. {[}Samia, M. Sanad, Mahmoud, A. El-Baz, Omar, I. Ghonemy and Hassan, F. Abo El-Nazar. Histopathological and Immunohistochemical Studies on the Adrenal Cortical Tumors of Egyptian Patients. Life Science Journal 2011; 8(4):970-978]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 124
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