Correlation Between CSF And Plasma Biochemical Markers With The Clinical Outcome Due To Spinal Cord Ischemia During Thoracoabdominal Aortic Aneurism Repair

body response to aortic surgery has been proposed as an excellent model of studying acute cytokinemia. No study has attempted to separate the body’s response to surgical trauma prior to aortic cross-clamping from the ischemia/reperfusion period. We tested the hypothesis that differences between surgical trauma (phase 1) and aortic cross-clamping/reperfusion (I/R, phase 2) responses will be revealed by comparing the kinetic profiles of cytokines in cerebral spinal fluid (CSF) and plasma. kinetic profiles of biomarkers have demonstrated to reveal differential release patterns for cytokines, neurotransmitters or oxidative stress biomarkers that distinguish between surgical trauma prior to aortic cross-clamping (phase 1) and aortic cross-clamping/ischemia-reperfusion periods (phase 2) in central (CSF) and peripheral (plasma) compartments.