Prevalence of Pseudomonas Aeruginosa, Its Antibiotic Susceptibility and Resistance Mechanisms to Antibiotics in ICUs

Pseudomonas aeruginosa (P.aeruginosa) is a Gram-negative, aerobic rod belonging to bacterial family Pseudomonadaceae. It is a free-living bacteria commonly found in soil, specific and multi-drug, are important determinants of intrinsic and/or acquired resistance water, plants, and animal.Efflux mechanisms of resistance, both drug to antimicrobials .The efflux decreases the antibacterial activity of unrelated drug families and can be considered as general resistance mechanism that cooperates with target mutations, reduced membrane permeability or drug modifications. This study aimed to determine the effect of verapamil (efflux pump inhibitor) on MICs of levofloxacin, ciprofloxacin and norfloxacin against P.aeruginosa isolates.