Value of protein-creatinine ratio in spot morning urine sample in patients with systemic lupus erythematousus

Systemic lupus erythematous (SLE) is a multi-system disease with unknown origin and variable symptoms. Kidneys are one of the most important organs that could be involved in SLE. Renal disorder is common however, the majority of patients have no clinical presentation .This study was performed to evaluate the correlation of Protein–Creatinine ratio in spot morning urine specimen and 24 hr urine protein excretion for prediction of significant proteinuria in patients with SLEThe study was performed on 30 subjects SLE patients who were chosen randomly and diagnosed according to the American College of Rheumatology revised criteria for the classification of systemic lupus erythematousus.All patients were subjected to full history taking, complete clinical examination, disease activity assessment by the SLEDAI score.All cases were subjected to laboratory investigations including:a. Complete blood picture.b. Erythrocyte sedimentation rate (first hour).c-C- reactive protein.d-C3 and C4.e-ANA. done by indirect immunoflurescence.f-Anti-dsDNA test a quantitative indirect enzyme immunoassay forthe detection inhuman serum or plasma of the IgG andIgMclasses of auto antibodies specific for (ds) DNA(DiaSorinStillwater, Minnesota 55082-0285, U.S.A.).