Early Goal Directed Therapy In Management Of Severe Sepsis And Septic Shock In Emergency Department

The systemic inflammatory response syndrome can be self-limited or can progressto severe sepsis and septic shock. Persons with a weakened immune system are mostlikely to develop sepsis, but the detrimental processes that may ultimately lead to thedeath of the patient are mostly caused by an exaggerated, systemic response to aninfection.Infections are fought in the body by both cellular defenses, including monocytes,macrophages, and neutrophils, and humoral defenses incorporating antibodies and thecomplement pathways.EGDT can be summarized in the following points :-1. Early recognition and management of severe sepsis/septic shock optimizes outcome .2. Continuous monitoring of vital signs , pulseoximetry , and urine output and initiallaboratory testing3. Simultaneously , a source of infection should be sought4. Empiric antibiotics should be initiated as soon as possible .