The Role of corneal collagen cross-linking in the treatment of keratoconus

Keratoconus is a corneal degeneration characterized by bilateral conical protrusion and corneal thinning. The average age of appearance of keratoconus is the second decade of life. The course of the disease varies from slight irregular astigmatism to severe visual impairment due to increasing protrusion and subepithelial scarring. Because of the young age of the patients, keratoconus often has a significant negative effect on quality of life.The biomechanical characteristics of the cornea result from the collagen scaffold and collagen compound and their bonding withthe collagen fibrils. Biochemical and immunohistochemical studies of the matrix’s proteoglycans show differences between normal and keratoconic corneas. Enzymatic alterations with an increased expression