Evaluation of some fibrinolytic factors for assessment of Lower Extremity Arterial Disease (LEAD) in Diabetic patients

This study was carried out in the Clinical Pathology and Internal Medicine Departments, Faculty of Medicine, Zagazig University Hospitals.The study included 57 subjects classified into 3 groups.Group I: It included 13 apparently healthy subjects.Group II: It included 22 insulin-dependent diabetic patients. They were sub-classified into 15 NON LEAD and 7 LEAD.Group III: It included 22 non insulin- dependent diabetic patients. They were sub-classified into 15 NON LEAD and 7 LEAD.All patients and control subjects were subjected to the followings:1- Full history taking.2-Complete clinical examination.3-Complete blood picture (CBC).4-Prothrombin time (PT) and Partial thromboplatin (PTT).5-C reactive protein (CRP).6-Liver and kidney functions tests fasting and two hours post prandial serum glucose.7-Lipid profile (total cholesterol, triglycerides, HDL- cholesterol).8- Specific laboratory investigations:• Glycosylated haemoglobin(HbA1c).• Assay of fibrinogen.• Assay of tissue plaminogen activator (t-PA)..