SUMMARY AND CONCLUSIONAD has been linked to several gene clusters on multiple chrosomes that are associated with elevated IgE level and ashma. Interestingly, these gene loci are in close proximity to loci linked to psoriass and some other skin diseases (Shaw, 2006).IL-13 gene is located at the chromosome 5q31-33 region where both linkage and association studies have previously provided evidence for susceptibility genes for AD, bronchial hypersensitivity, asthma and total serum IgE levels (Ober et al., 1998).The aim of this work was to identify the allelic distribution of G4257A and G4738A polymorphisms of IL-13 in atopic dermatitis patients, their relationship with atopic markers and the functional impact of SNP/SNP interaction within the same gene.This study was carried out in Outpatient Clinic of the Dermatology and Venereology department, Faculty of at Medicine, Zagazig University. The study included 25 patients with atopic dermatitis of both sexes with an age ranging from 8-22 years and 13 normal control subjects (age and sex matched). All patients met the diagnostic criteria for atopic dermatitis, as defined by Hanifin and Rajka. (1980). None of those patients had other atopic conditions (asthma, rhinitis or conjunctivitis) nor received antihistamines, or systemic or topical corticosteroids during the period of the last 3 weeks before clinical evaluation. The severity of atopic dermatitis was measured by using the SCORAD index. AD was considered mild, moderate, and if the SCORAD index was less than 25, between 25 and 50 and 50 respectively.Both patients and healthy control were subjected for the following assessment:• Full history taking and clinical examination.