| Abstract: |
Abstract1- Heptocellular carcinoma (HCC) showed an increasing trend in the past few years that could be attributed to more exposure to the different risk factors including environmental pollutants.2- At the present time, there is no single staging system that embraces all the needs of all the physicians caring for patients with (HCC), including accurate categoristion of all patients, determination of appropriate treatment options, and establishment of prognosis.3- There was a significant difference between stages I, II, III regarding S.creatinine, P.T, INR. SGPT, SGOT, S.Billirubin, HB, WBCs, Platelets and S. Albumin. (P value < 0.05)But There was no significant difference between stage I, II, III reading AFP. (P value > 005)4- By ultrasound there was a significant difference between stages I, II, III regarding (liver size, focal lesion site, spleen) (P value < 0.05). But There was no significant difference between stages I, II, III regarding (cirrhosis, ascitis, kidney) (P value > 0.05)5- By CT there was a siginificant difference between stages I, II, III regarding (liver size, focal losion site, ascitis, portal vien lumen, spleen) (P value < 0.05).But There was no significant difference between stage I, II, III regarding to (cirrhosis, kidney, metastasis) (P value > 0.05)6- According to Okuda classification, we found that: Number of patients in stage II were more than the number of patients in stage I and the number of patients in stage 1 were more than number of patients in stage 3.II > I > IIII- This study recommends, prevention of both HCV and HBV infection by active immunisation early in childhood and population at high risk is important. Raising the standard of environmental and antipollutant measures with proper sewage disposal and clean water supply is mandatory.II- Screening of patients with chronic HCV and/or HBV (with or without cirrhosis) aided by abdominal US and serum AFP levels for earlier detection of small lesions, remains the only realistic approach for in proving treatment of HCC patients but its cost effectiveness is uncertain.III- AFP alone not diagnostic of HCC but we must use non invasive procedures as contrast enhanced US, multidetection row C.T and Magnetic Resonance imaging.
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