Growth Hormone Secretion in Type-I Diabetes: Relation to Somatic Growth and Development of Nephropathy

diabetes mellitus type 1 is the most common endocrine metabolic disorder of children and adolescents, due to decreased insulin secretion or activity, or both. It is characterized by chronic hyperglycemia associated with the development of microvascular complications (retinopathy, neuropathy and nephropathy).Somatic growth of diabetic children depends on the adequacy of insulin administration and degree of metabolic control. Under-insulinization and poor diabetes control can result in growth delay. On other hand, improved insulin delivery usually results in normalization of growth but can produce rapid development of diabetic nephropathy, through increased secretion of growth hormone (GH) and insulin growth factor-I (IGF-I).Objective:This study aimed to study GH/IGF-I axis and its relation to actual growth and glycemic control, as well as its relation to the development of diabetic nephropathy..