RESPIRATORY DISTRESS DISorderS IN NEWBORN

The present study evaluated the physiological significance of ET-1, NO, and antioxidant material (ascorbic acid) in newborns with respiratory distress disorders of different etiologies e.g. transient tachypnea of newborn (TTN), persistent pulmonary hypertension (PPHN), meconium aspiration (MAS), and respiratory distress syndrome (RDS). Also, evaluated the role of other risk factors, i.e. preterm, low birth weight, and mode of birth, in regulation of these vasoactive materials balance and imbalance.Disturbance of respiration in the immediate postnatal period may have originated in utero, in the delivery room, or in the nursery. A wide variety of pathologic lesions may be responsible for one or more of the signs of respiratory distress (Roberts and Dalziet, 2006).The pathogenesis of respiratory distress disorders is complex and involves a variety of oxidative insults which play extremely important role in injury process (Gitto, 2002).