serum leptin concentration in insulin resistance syndrome in type 2 diabetic patients

Background: Leptin, an adipose tissue-derived hormone of the obesity (OB) gene, is an important regulator of energy metabolism and may be associated with the occurrence of diabetes and insulin resistance in humans. Insulin resistance syndrome, is characterized by decreased tissue. Sensitivity to the action of insulin leading to a compensatory increase in insulin secretion. We aimed to evaluate the relation between serum leptin.Methods: 80 persons were slected as follow:30 patients type 2 diabetes with insulin resistance syndrome 10 males and 20 females with mean age XSD of 44.25.8 with range 36-56. 30 patients type 2 diabetes without insulin resistance syndrome 20 females and 10 males with mean age XSD of 44.76.0 with range 33-53.20 healthy persons as cotrole .We estimated both fating serum leptin and insulin to all subjectsResults: There was high significance of serum leptin of group I and group II when compared to group III (control group) (P<0.001). And high significance of serum insulin of group I when compared with other groups (P<0.001) and high significance when compared group I versus group II (P<0.001).Also there was high significant difference as regard BMI. FBs P.P.B.S and lipid profile and serum insulin when correlated with serum leptin(r:0.67- respectively .