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Novel Jojoba Oil-Based Emulsion Gel Formulations for Clotrimazole Delivery
Faculty
Pharmacy
Year:
2011
Type of Publication:
Article
Pages:
239-247
Authors:
Shahin, Mostafa, Hady, Seham Abdel, Hammad, Mohammed, Mortada, Nahed
DOI:
10.1208/s12249-011-9583-4
Journal:
AAPS PHARMSCITECH SPRINGER
Volume:
12
Research Area:
Pharmacology \& Pharmacy
ISSN
ISI:000288954100026
Keywords :
Carbopol 934 P, clotrimazole, emulgel, emulsion gel, HPMC, microbiological evaluation, rheology, stability
Abstract:
Jojoba oil-based emulgel formulations were prepared using different concentrations of various gelling agents, such as hydroxypropyl methylcellulose (HPMC) and Carbopol 934 P and combination of both. The prepared emulgels were physically evaluated for their stability after temperature cycle test, centrifugation and long-term shelf storage for 1 year at room temperature. The in vitro release at 37A degrees C was studied to define the effect of the concentration and type of the gelling agent. A comparison between the formulated emulgels and two commercially available products, CandistanA (R) and CanestenA (R) creams, was carried out to judge their efficacy and stability. The prepared emulgels exhibited non-Newtonian shear thinning behavior with little or no thixotropy. Four emulgels showed excellent stability as they demonstrated consistent rheological model under different treatment conditions. The in vitro release test showed variation in the extent of percent drug released. The drug release from the commercial preparation was lower than some of the prepared emulgel formulae. One formula containing combination of the two gelling agents (HPMC and Carbopol 934 P), showed excellent stability and high extent of clotrimazole release was microbiologically evaluated against Candida albicans using cylinder and plate method. The selected formula showed superior antimycotic activity compared to the commercially available formulation. Further in vivo animal studies for the obtained stable formula is recommended.
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