For more than a century there has been awareness of the fact that the eye is not a perfect optical system and that it suffers optical aberrations other than defocus and astigmatism. Optical aberrations in the human eye impose a major physical limit on vision .Customized ablation is an ablation pattern that attempts to optimize the eye’s highly sophisticated optical system based on the individual eye’s optics and anatomy, as well as the patient’s needs.There are two forms of customization,the first measures the wavefront error of the entire eye and treats based on these measurements while the second measures the ocular aberrations detected by corneal topography .Wavefront analysis is a promising technology that provides an advanced method for measuring optical distortions in the eye. Measuring and treating these distortions goes beyond nearsighted, farsighted, and astigmatism determinations that have been used for centuries. As a result, physicians can now customize the refractive procedures according to each individual patient’s unique vision correction needs. The treatment is unique to each eye, just as a fingerprint is unique. Applications of wavefront-guided ablation are myopia, asymmetrical ablation after laser, post-LASIK night vision complaints, irregular astigmatism, optimizing IOL and contact lenses. The incidence increases with decreasing gestational age.Several mechanisms have been proposed to explain apnea of prematurity:1- Immaturity of respiratory center.2- Decreased sensitivity of chemoreceptors to hypoxia or hypercapnea.3- Active reflexes invoked by stimulation of the posterior pharynx eg. Vigorous use of suction catheter in the pharynx .Most cases of apnea are usually detected in infants at high risk. History and physical examination for evaluation of the infant and detection of possible cause of apnea . Routine monitoring for apnea in infants at risk includes heart and respiratory rates as well as oxygen saturation.Pneumogram may be obtained to determine the frequency and severity of respiratory pauses and a polysomnogram may be used to measure cardiorespiratory pattern, muscular activity, transcutaneous oxygen level, oral or nasal airflow, and chest wall and abdominal movements.Other tests may be undertaken, depending on infant circumstances ,including EEG, ECG, chest radiograph, CSF analysis, CBC ,ABG,blood glucose , Ca and electrolye level.Treatment of neonatal apnea includes treatment of the cause.