Relationship between HCV Viral Load and HCC

Hepatitis C virus is carried by about 0.01-2% of blood donors world wide. The problem in Egypt resides in high prevalence of positive anti-HCV in healthy subjects who are considered as possible reservoirs of infection for the population. The results of HCV seropositivity widely ranged from 5.2 to 24.4%. The prevalence of anti-HCV in blood donors in Sharkia Governorate was 17.6%.Eighty percent of patients will develop chronic hepatitis and 20% will go into cirrhosis. Liver cell failure develops often after 10 or more years of disease. Bleeding from esophageal varices is unusual until late, the first episode of variceal bleeding is one of’ the most frequent causes of death in patients with liver cirrhosis.Hepatocellular carcinoma (HCC) is a common malignancy worldwide. It is the fifth most common cancer and the third leading cause of cancer death in the world.HCC is the most common terminal complication of chronic inflammatory and fibrotic liver disease.