Epidemiological stdy of immune thrombocytopenic puprura in the last five years in pediatric hematology unit,Zagazig university children hospital

Idiopathic thhrombocytopenic purpura occurs at all ages , in acute and chronic forms . Children mainly have the acute form which usually follow a recent viral illness , occurs equally in both sexes , and generally resolves within six months . Chronic I.T.P. occurs more often in adults , with insidious onset , and more in females ( Schwartz , 2007 ).Both forms are now thought to be due to an anti-platelet antibody , usually of IgG class ( platelet-associated IgG), which coats autologous platelet and lead to their phagocytosis and destruction by the reticulendothelial system , mainly to spleen ( Carcao et al , 2003 )The important prognostic concern is life-threatening intracranial hemorrhage which is rare , but it is responsible for most death in childhood ITP and requires early recognition and aggressive management (Philip lanzkowsky , 2005 )The clinical presentation as regards petechiae , purpura , ecchymosis or bleeding from orifices in a severely thrombocytopenic child with minimal or no trauma is the first presentation of I.T.P. ( Chandra et al , 2006 ) .