Telomerase activity in acute leukemias in children

In conclusion, the limited number of studies regarding telomere length and TA in children represents a challenge to investigate the chromosome end biology in normal and disease states in childhood. Improvement of the techniques used to evaluate TA gives us hope that the results of such research may be applied in clinical practice in the near future.Telomere length measurement and TA assays could be useful tools to assess the aggressiveness of a malignancy and to monitor treatment progress, while the prospect of using telomerase as a potential target for antitumor therapy promises a new era in the treatment of cancer.Our results suggested that- Telomerase activation play an important roles in leukemogenesis and disease progression by proliferation and immortalization of leukemic blasts and can be considered as new marker for predicting the response to therapy and outcome in acute childhood leukemia and future targets to anticancer therapy.- Follow up for our patient to know 5 years survival rate and compare it with telomerase levels to know its long term predictive value as prognostic factor