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SYNTHESIS AND PHARMACOLOGICAL ACTIVITIES OF SOME DIBENZOPYRAZOLOCINNOLINES AND DIBENZOPYRIDAZINOQUINOXALINES
Faculty
Science
Year:
2011
Type of Publication:
Article
Pages:
101-107
Authors:
Amer, A. M, El-Farargy, A. F, Yousif, N. M, Fayed, A. A
Journal:
CHEMISTRY OF HETEROCYCLIC COMPOUNDS SPRINGER
Volume:
47
Research Area:
Chemistry
ISSN
ISI:000291528900014
Keywords :
pyridazine, pyrimidine, triazine, antiparkinsonian activity
Abstract:
Derivatives of three new classes of heterocyclic compounds have been synthesized. The first class comprises the synthesis of pyrimidino- and imidazolopyrazolopyridazine using 11H-dibenzo{[}f,h]pyrazolo{[}3,4-c]cinnoline-13-amine. The second class involves the synthesis of triazine derivatives using 11H-dibenzo{[}f, h]pyrazolo{[}3,4-c]cinnoline-13-diazonium chloride. The third class deals with the synthesis of polycyclic compounds using dibenzo{[}f,h]pyridazino{[}4,5-b]quinoxaline-10,13-diamine. The pharmacological screening has shown that several of these compounds have good antiparkinsonian activities comparable to Benzatropine. The detailed synthesis, spectroscopic data, and pharmacological properties are reported.
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