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SPECTROPHOTOMETRIC DETERMINATION OF TADALAFIL IN PURE AND DOSAGE FORMS
Faculty
Science
Year:
2011
Type of Publication:
Article
Pages:
125-132
Authors:
Gouda, Ayman A, Al Kaf, Ali
DOI:
10.2298/CICEQ100816062A
Journal:
CHEMICAL INDUSTRY \& CHEMICAL ENGINEERING QUARTERLY ASSOC CHEMICAL ENG
Volume:
17
Research Area:
Chemistry; Engineering
ISSN
ISI:000293606100002
Keywords :
tadalafil, spectrophotometry, ion pair complex, bromocresol purple, methyl orange
Abstract:
Two simple, rapid, and extractive spectrophotometric methods were developed for the determination of tadalafil (TDF) in both pure and tablet dosage form. These methods are based on the formation of ion-pair complexes between the basic nitrogen of the drug with bromocresol purple (BCP) and methyl orange (MO) in acidic buffer solution. The formed complexes were extracted with chloroform and measured at 410 and 425 nm using BCP and MO, respectively. Beer's law was obeyed in the range 20-20 mu g mL(-1) with correlation coefficient (n = 6) >=.0.9996. The molar absorptivity, Sandell sensitivity, detection and quantification limits were also calculated The composition of the ion pairs was found 1:1 by Job's method The proposed methods have been applied successfully for the analysis of TDF in pure and in its dosage forms. These developed methods were validated for accuracy and precision.
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