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Synthesis of Coumarin Conjugates of Biological Thiols for Fluorescent Detection and Estimation
Faculty
Pharmacy
Year:
2011
Type of Publication:
Article
Pages:
1494-1500
Authors:
Abo-Dya, Nader E, El-Feky, Said A, Katritzky, Alan R, Abdel-Samii, Zakaria K, Ibrahim, Tarek S, Tala, Srinivasa R
DOI:
10.1055/s-0030-1259991
Journal:
SYNTHESIS-STUTTGART GEORG THIEME VERLAG KG
Volume:
Research Area:
Chemistry
ISSN
ISI:000289713800024
Keywords :
fluorescence, acylation, coumarin, thiols, benzotriazoles, peptides, amino acids, heterocycles
Abstract:
Coumarin-labeled thioesters are efficiently prepared from biological thiols using N-coumarin-3-carbonyl benzotriazoles. Absorption (lambda(abs)), fluorescence (lambda(em)) wavelength maxima and quantum yields (phi) for the thioesters are measured in buffer solution at physiological pH 7.4. Quantum yields (phi = 0.0318-0.1068) of four of the products are higher than their precursor 7-methoxy-3-(1H-benzotriazol-1-ylcarbonyl)-2H-chromen-2-one (phi = 0.0195), suggesting that derivatives of this type could be suitable for quantitative thiol assays.
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