Apoptosis In Liver Diseases

The Aim Of The WorkThe Aim Of This Work Was To Determin Definition, Significance And Mechanisms Of Apoptosis And To Determine The Role Of Apoptosis Dysregulation In The Pathogenesis Of Different Liver Diseases.The development of the term apoptosisAlready since the mid-nineteenth century, many observations have indicated that cell death plays a considerable role during physiological processes of multicellular organisms, particularly during embryogenesis and metamorphosis (Gluecksmann, 1951; Lockshin and Zakeri, 2001). The term programmed cell death was first introduced in 1964, proposing that cell death during development is not of accidential nature but follows a sequence of controlled steps leading to locally and temporally defined self-destruction (Lockshin and Williams, 1964). Eventually, the term apoptosis had been coined in order to describe the morphological processes leading to controlled cellular self-destruction and was first introduced in a publication by Kerr, Wyllie and Currie )Kerr et al., 1972).The significance of apoptosis