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Synthesis, structure and imaging of oligodeoxyribonucleotides with tellurium-nucleobase derivatization
Faculty
Engineering
Year:
2011
Type of Publication:
Article
Pages:
3962-3971
Authors:
Hassan, Abdalla E. A, Sheng, Jia, Zhang, Wen, Zhou, Jianfeng, Xu, Bingqian, Soares, Alexei S, Huang, Zhen
DOI:
10.1093/nar/gkq1288
Journal:
NUCLEIC ACIDS RESEARCH OXFORD UNIV PRESS
Volume:
39
Research Area:
Biochemistry \& Molecular Biology
ISSN
ISI:000290589500045
Keywords :
Synthesis, structure , imaging , oligodeoxyribonucleotides with tellurium-nucleobase
Abstract:
We report here the first synthesis of 5-phenyl-telluride-thymidine derivatives and the Te-phosphoramidite. We also report here the synthesis, structure and STM current-imaging studies of DNA oligonucleotides containing the nucleobases (thymine) derivatized with 5-phenyl-telluride functionality (5-Te). Our results show that the 5-Te-DNA is stable, and that the Te-DNA duplex has the thermo-stability similar to the corresponding native duplex. The crystal structure indicates that the 5-Te-DNA duplex structure is virtually identical to the native one, and that the Te-modified T and native A interact similarly to the native T and A pair. Furthermore, while the corresponding native showed weak signals, the DNA duplex modified with electron-rich tellurium functionality showed strong topographic and current peaks by STM imaging, suggesting a potential strategy to directly image DNA without structural perturbation.
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