Staphylococcal Aureus Colonization And Its Toxins In Some Skin Diseases

An important role of S. aureus colonization of the skin is its potential to modify the course of dermatologic diseases. In particular, S. aureus enterotoxins of types A through E and the TSST-1 have been shown to trigger exacerbation of AD, psoriasis, CTCL and erythroderma.The aim of the work is to assess the prevalence of S. aureus colonization in AD, psoriasis, CTCL and erythroderma. Also to correlate the severity of these diseases with the staphylococcal enterotoxins production.Our study was conducted on one hundred patients (40 patients with atopic dermatitis, 40 patients of psoriasis, 10 patients of cutaneous T cell lymphoma and 10 patients suffering from erythroderma and) and 20 healthy control.All patients included in this study underwent the following protocol for evaluation: detailed history taking, clinical examination, histopathological examination and bacteriological study (Staphylococcus aureus isolation and identification, test for enterotoxin production by S. aureus and detection of staphylococcal enterotoxins A, B, C, and D genes by the polymerase chain reaction).The prevalence of S. aureus colonization and staphylococcal enterotoxins production in the skin of patients with AD, psoriasis, CTCL and erythroderma was high compared with healthy control and it was correlated with the severity of these diseases. So we can conclude that S. aureus and its toxins have a significant role in the pathogenesis of these dermatological diseases under study.