evaluation of roles of adiponectin hormone and lipoprotein lipase gene polymorphism in pathogenesis of childhood simple obesity

Obesity is a global nutritional concern which is increasing at alarming rates throughout the world (Styne, 2001) it occurs when energy intake chronically exceeds energy expenditure (Raine et al., 2001 In the present study over weight was defined as BMI more than 85th percentile for age and sex and obesity was considered when BMI value was greater than 95th percentile for age and sex compared to standard Egyptian growth charts instructed by faculty of medicine Cairo university and endocrinal department (Kasr El-Eini, 2004 A case and control study was organized to calculate prevalence of over weight and obesity among children and evaluation of some risk factors of obesity in screening group 20 children were examined 6 males and 12 females their age was 6-10 years and their (BMI) was 25.9-29.9 kg/m2 and their age ranged between 6-10 years and 20 control group of children with normal body mass index BMI Blood sampling were collected for further assessment of serum cholesterol, serum triglyceride and level of fasting plasma adiponectin and for DNA analysis for detection of LPL Hind III polymorphism As longitudinal studies in primates suggest that adiponectin decreases with weight gain in human (Hotla et al., 2001), it is expected that weight loss results in increased adiponectin expression Diet-induced weight loss in obese subjects resulted in significant increases in adiponection plasma and mRNA levels such that the changes in adiponectin levels correlated with improvements in insulin sensitivity In this study there was significant decrease of serum adiponectin in cases than control In this study there was non significant relation between adiponectin level and LPL genotype distribution in case and control Additional genetic information is showing that minor variations in the LPL gene also modulate lipoprotein profiles, as information has accrued on uptake of lipids by tissues and how this in turn regulates both lipid and glucose metabolism.