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Synthesis of Selenium-Containing Amino Acid Analogues and Their Biological Study
Faculty
Science
Year:
2011
Type of Publication:
Article
Pages:
261-269
Authors:
Abdel-Hafez, Sh. H, Saad, H. A, Aly, M. R. E
DOI:
10.1134/S1068162011030034
Journal:
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY MAIK NAUKA/INTERPERIODICA/SPRINGER
Volume:
37
Research Area:
Biochemistry \& Molecular Biology; Chemistry
ISSN
ISI:000295532400001
Keywords :
pyridineselenol, quinolineselenol, amino acid, anti-bacterial activities, anti-fungal activities
Abstract:
Synthesis of selenium-containing amino acid analogues is described. These compounds were prepared in a concise and short synthetic route in good yields by nucleophilic substitution reaction of pyridineselenol and quinolineselenol derivatives with N-phthaloylglycyl chloride followed by hydrazinolysis. The newly synthesized compounds were screened against different strains of bacteria and fungi.
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