updates in management of organophosphorus compounds poisoning

IntroductionSince the removal of organochlorine insecticides from use, organophosphorus insecticides have become the most widely used insecticides available today.Globally, the poisoning due to insecticide is responsible for approximately three million episodes, 200.000 of them are dying each year.Although the number of deaths indicates that this is a major public health problem, of the same order of magnitude as diabetes or human immunodeficiency virus, there is little coordinated effort being applied to find solutions to the problem of insecticide poisoning.There’s a wide range of problems concerning its therapeutic approach. No new OP antidotes have been marketed in the last fifty years.Evidence-Based MedicineThe explosion in biomedical publishing in the latter half of the 20th century makes keeping up with primary research an impossible feat and makes of systemic reviews a necessity. A review of only leading journals is likely to give an overoptimistic view of therapy effectiveness.Evidence-based medicine is the process of systematically reviewing, appraising and using clinical research findings to aid the delivery of optimum clinical care to patients. The practice of evidence-based medicine means integrating individual clinical expertise with the best available external clinical evidence from systematic research.Evidence-based medicine remains a relatively young discipline whose positive impacts are just beginning to be validated, and it will continue to evolve.