Histological Study on the Effect of Experimentally Induced Diabetes on the Urinary Bladder of Adult Male Albino Rats(Light & Electron Microscopy Study)

Histological Study on the Effect of Experimentally Induced Diabetes onthe Urinary Bladder of Adult Male Albino Rats (Light & ElectronMicroscopy Study)Thesis Submitted in partial fulfillment for master degree in HistologyBY: EMAN MOSALLEM MOHAMEDM.B., B.ch., Demonstrator of Histology Faculty of Medicine-Zagazig UniversityThe objective: is to study the possible histological changes that mayoccur in the urinary bladder of the adult male albino rats due todiabetes. Furthermore, the effect of insulin therapy on thesehistological changes. Design: retrospective study. Setting: theHistology Department, Zagazig university hospital. Materials andmethod: Thirty healthy adult male albino rats were utilized in thisstudy, they were classified into three groups (10 animals each). GroupA: the control group that received no treatment, Group B:experimentally induced diabetic rats. Group C: treated with insulinafter induction of diabetes. Results: Several changes weredemonstrated in the diabetic urinary bladder. The thickness of theurothelium was increased. The cells showed dark nuclei, largelenticular vesicles and there were widening of the intercellular spaces.The lamina propria showed thick layers of collagen fibers and themuscle fibers were thickened. Conclusion, it become clear that theeffect of diabetes on the urothelium causes disruption of its barrier andthat leads to cystitis which is common with diabetes.Diabetes is a famous disease that affects many organs in the bodycausing morphological and functional changes in these organs.Urinary bladder troubles are common complications of diabeticpatients and most of the available literatures are dealt with thephysiological alterations that occur in the urinary bladder of thesepatients. So, the aim of this work is to study the underlying histologicalchanges in experimentally induced diabetic rats. Furthermore, the effectof insulin therapy on these expected histological changes.