Role of Adhesion Molecules in Hematological Malignancies

Introduction :Adhesion molecules play a key role in many biologic processes such as hemostasis and inflammation. Their function is to orchestrate cell-cell and cell-extracellular matrix interactions and is complex and dynamic. They constitute a structurally diverse group of cell membrane receptors belonging to distinct families, that is, the selectin, the integrin, the immunoglobulin and the CD 44 families (Paul and Steven 2000)Aim of the work :This essay aims at reviewing the alteration in the different adhesion molecules and their possible role in the pathophysiology of relevant hematological malignancies.Methodology :A-Detection of adhesion molecules can be achieved through:I-Flow cytometry- II-ELISA:III-Immunohistochemical analysis: IV-PCR:V-Immunoperoxidaze staining:VI-Direct immunofluoresence staining:B-Functional or adhesion assay:1-Endothelial-blast cell attachment assay:2-Flow cytometric adhesion assay (FCAA):3-Chromium-51 adhesion assay