KIDNEY AND PANCREAS TRANSPLANTATION IN DIABETIC RENAL FAILURE PATIENTS

Diabetes mellitus is an important and growing problem worldwide; where diabetic nephropathy is the leading cause of renal failure, for which the most ideal treatment is simultaneous pancreas-kidney transplantation. Islet cell transplantation is a better alternative for pancreas transplantation. Pancreas or islet transplant alone are considered with restricted indications for diabetics with sever metabolic derangements. Pre-transplant recipient and donor evaluation is mandatory to assure both acceptable recipient life expectancy and donor safety. The recipient, then, receives immunosuppression; and may encounter some complications whether technical, graft rejection, increased incidence of infection and malignancy, or systemic complications.