Anti Streptolysin O Titre Profile In Normal Children and Children Suffering from Recurrent Tonsillopharyngitis

Tonsillitis and tonsillopharyngitis is common pediatric illness in children from 5 – 15 years and rarely occur below 6 months of life this disease caused by group A beta hemolytic streptococci (gram positive cocci and manifested by high fever, dysphagia, abdominal pain and vomiting transmitted through contact with infected person. This disease represent high problem due to its complications as rheumatic fever.Tonsillopharyngitis is diagnosed by full medical history, clinical examination, laboratory investigation as throat culture which remain gold stander for diagnosis of tonsillopharyngitis, antistreptolysin O titre.This work conducted on 420 children which divided into 4 groups:Group I: consisted of 100 apparently healthy subjects range from 3 – 11 years from both sexes, 46 (46%) males and 54 (54%) females as control group.Group II: This group consisted of 100 children suffering from acute tonsillitis, range from 4 – 12 years from both sexes 46 (46%) males and 54 (54%) females.Group III: This group consisted of 100 patients of rheumatic fever, 7 – 15 years from both sexes 42 (42%) males and 58 (58%) females.Group IV: This group consisted of 120 patients complaining from recurrent tonsillopharyngitis at least 6 attacks per year, 3 – 15 years from both sexes 51 (42.5%) males and 69 (57.5%) females.All patients underwent the following:1- Full clinical history taking, personal history and history of present illness.2- Full clinical examination for tonsils, joint, heart and skin.3- Workup all patients in four subjected groups examined for:- Complete blood count (CBC).- Erythrocyte sedimentation rate.- C.reactive protein (CRP).- Antistreptolysin O titre.The later is latex agglutination test which demonstrate the body’s reactition to an infection caused by group A, beta hemolytic streptococci.The results of our study revealed that no significance difference between the patients and control groups as regard age and sex, high positivity of ASO among group II than group III and IV (100%), 93% and 76.7% respectively) than group I (12%) with high significance difference.Higher positivity of mean ASO titre was recorded among group II than group III and IV (872  506.54, 77.849  500.84 and 347.83  223.60 respectively) than group I (333.33  77.85) with highly significance difference (P < 0.001).Finally ASO is indicator for group A streptococcal infection and follow up of its complication as rheumatic fever.