Hyperfunctional facial wrinkles are caused by overactivity of the facial expression muscles.Botulinum toxin is an exotoxin produced by clostridium botulinum bacterium. It is a muscle relaxing agent. When botulinum toxin is injected directly into the selected overactive muscles which are involved in the hyperfunctional wrinkles, these muscles will be relaxed.Botox vial containing approximately 100 u of botulinum toxin-A, Twenty patients with different types of hyperfunctional facialwrinkles were included in the present study . They included ten patients(50%) with transverse forehead lines, four patients (20%) with glabellar frown lines, and six patients (30%) with crow’s feet.Pregnant , lactating women and neuromuscular diseases patients, pre-existing brow ptosis or facial asymmetry were excluded and all aged between 20 and 45 .In this thesis, all of the studied patients had cosmetic improvement. Good to moderate improvement was found in 90%, 75%, and 66.7% ofPatients with transverse forehead lines, glabellar frown lines, and crow’sfeet respectively. While, mild improvement was attained in 10%,25% and 33.3 of patients with transverse forehead lines glabellar frown lines and crow’s feet respectively.All patients of wrinkles were satisfied of the cosmetics resultsThe length of action of Botox was ranged from 4-6 months .Botox injection is relatively a simple procedure without any surgical intervention and can be done rapidly in an office setting.In conclusion, botulinum toxin-A (Botox) is a safe and effectivetherapy for management of hyperfunctional facial wrinkles including transverse forehead lines ,glabellar frown lines,and periorbital wrinkles (crow’s feet).