| Abstract: |
Maternal diabetes mellitus considerably complicates the condition of the fetus through an increased risk of congenital malformations, premature delivery and increased perinatal mortality and morbidity. It also results in neonatal hypoglycemia, macrosomia and a transient myocardial hypertrophy.In this study we tried to study the left ventricular systolic and diastolic functions in infants of diabetic mothers with good diabetic control as possible as we can.The study was conducted in Zagazig University, Pediatric department, Echocardiographic unit.In this study we studied 30 full term newborn infants of diabetic mother (IDM).All these infants were subjected to the following:*Full history taking.*Full clinical examination including anthropometric measures (weight, length and H.C.) were done to all of them.*Measuring the blood glucose.*Doppler Echocardiography; systolic & diastolic LV function were assessed.Similar Doppler examinations were performed in 30 healthy control full term neonates at the age of 2__5 days.In this study the rapid ventricular filling (E-wave) was significantly increased in control group compared to IDM group. But atrial contraction (A-wave) did not show asignificant difference between the two groups. Early /atrial ratio, in this study, was significantly decreased in IDM compared with control groupWhen assessing left ventricular diastolic function, the deceleration time of early diastolic filling was prolonged in the infants of diabetic mothers in comparison with the control neonates, and early duration showed highly significant difference, and Diastolic filling time showed highly significant increase in IDM when compared with control group.When assessing systolic function on IDM, fractional shortening showing highly significant difference on comparison to control group. Fractional shortening area shows no difference between IDM and control group. Also, there is no significant difference between IDM and control group regarding IVS, LVID, LVED and LVPW during systole & diastole, and also there is no difference as regarding AT/Ao.When comparing gestational and pre-gestational subgroups in the IDM group, on regarding all the diastolic and systolic parameters, there is no any significant difference except for early acceleration time has been noticed.In conclusion, this study emphasis that; even with strict diabetic control in diabetic mothers, there is some deterioration in left ventricular function (especially diastolic) in their infants.
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